Alfie Bailey-Bearfield of Pancreatic Cancer UK said the charity had been raising concerns with the government and suppliers for more than a year and it was vital that officials intervened to try to boost supply.
"Thousands of people affected by pancreatic cancer rely on taking Pert tablets every time they eat simply to digest their food and absorb nutrients – something most of us take for granted," he said.
"It's totally unacceptable that they are still taking desperate measures which puts their health, wellbeing and their eligibility for treatment at risk," he added.
Dr Leyla Hannbeck, chief executive of the Independent Pharmacies Association said it was very difficult for her members to obtain supplies from the wholesaler.
"The shortages with Creon has been ongoing for so long and it seems no effective attempts are being made by officials to make the process easier for pharmacies and patients and to put robust plans in place to prioritise the availability of this product," she said.
"Instead they continue prolonging the current processes."
A Department of Health and Social Care spokesperson said it knew "how frustrating and distressing" medicine supply issues can be for patients and clinicians caring for them.
They added: "The European-wide supply issues with Creon are caused by a limited availability of raw ingredients and manufacturing capacity constraints.
"We are working closely with industry and the NHS to mitigate the impact on patients and resolve the issues as quickly as possible."
