Robbie Williams' won the icon award, in recognition of his 34-year career - from boyband hits like Could It Be Magic and Back For Good with Take That, to his record-breaking solo work on songs including Angels, Rock DJ, Feel and Come Undone.
Coming undone might also an apt description of his reaction to the award.
"When momentous things like this happen, it's just a hodge-podge of things coming at you from the universe," he said backstage.
"It's self-doubt and self-hatred mixed with ego and delusion and audacity.
"So it's very difficult to put your finger on what it feels like in the moment, other than you're supposed to say, 'I'm very grateful'. And I am."
2000s indie heroes Bloc Party won the outstanding song collection prize, while Berwyn's fierce and personal debut Who Am I, was named best album.
Best contemporary song was won by Sans Soucis for Circumnavigating Georgia, while best song musically and lyrically was won by Orla Gartland for Mine, beating the likes of Lola Young, Raye and Fontaines DC.
Mine is a quiet but hopeful ballad about overcoming a traumatic experience that Orla said "really affected my relationship with intimacy".
Accepting the prize, the Irish singer said she was proud to be an independent artist, because "I'm not sure what a boardroom of old guys would have known what to do with this song about bodily autonomy and reclaiming it".
Taking a similar approach was pop artist Self Esteem, who was given the visionary award.
She used her speech to implore the music industry to do more to protect young women from misogyny and online abuse.
"People are foaming at the mouth to ridicule you," she said. "People hate women, and sometimes [those comments] get in and stay there."
But she also took the opportunity to thank her mum and dad, Janet and Andy, who'd finally seen her win an award, "after coming down to see me lose the Mercury [Prize] twice".
"I'm so sorry about how much I swear and how many of my songs are about shagging," she added.