She gave birth to her son in Switzerland during the 90s, an experience she described as "profoundly transformative". She would go on to adopt three other children.
Fed up with life in the Swiss city of Zurich, Kouoh returned to Africa in 1996.
She worked as a curator in Senegalese capital city Dakar, before founding Raw Material Company, an expansive, independent art hub.
Just last week, and six years into her role as the director of South Africa's Zeitz Museum of Contemporary Art Africa, Kouoh reflected on her love for Dakar.
"Dakar made me who I am today," she told the Financial Times.
"It's the place I came of age professionally, where I really became a curator and an exhibition-maker... I'm in Cape Town now but, mentally, I live in Dakar. It's the one and only place for me."
When Kouoh took the top job at Zeitz, Africa's biggest contemporary art museum, the institution was in crisis.
Founding director Mark Coetzee had been suspended in 2018 following allegations of staff harrasment and later resigned.
Kouoh has been widely credited with turning Zeitz's fortunes around, leading it through the scandal, as well as the Covid pandemic.
"For me, it became a duty to salvage this institution," she told The Art World: What If…?! podcast.
"I was convinced that the failure of Zeitz, if it had failed would've been the failure of all of us African art professionals in the field, somehow indirectly."