More than four in 10 universities in England are expecting to be in a financial deficit by this summer, according to new report from the Office for Students (OfS).
The OfS, which regulates higher education providers, said universities were closing courses and selling buildings to cut costs, but "significant reform and efficiencies" were needed to turn the tide.
It said a drop in international students coming to the UK was the main reason for the worsening financial position.
Universities UK (UUK), which represents 141 institutions, said the report was "deeply sobering".