"A big thing for me now is, had I asked the questions or just looked for the signs, would the outcome be different?" she says.
The Vivienne was praised for speaking openly about ketamine abuse and the struggle of becoming sober while appearing on Drag Race UK, which aired in 2019.
Chanel is now hoping to continue that legacy by campaigning to encourage people to talk openly about substance abuse.
She believes the stigma around addiction, and her brother's successful career on stage and TV, meant James didn't seek professional help.
"He'd spoken openly on Drag Race about the battles he'd had with addiction, and he'd come through the other side of that," she says.
"He was at the height of everything he was doing and I think because he'd said it in such a open platform, it's really difficult to come back and say you're struggling again."
Chanel says she's concerned about the rise in young people taking ketamine, which she believes is in part because the drug is cheap and easily accessible.