The European Commission has signalled it has confidence in Meloni, and a spokeswoman said "any outreach to the US [was] very welcome".
However, the spokeswoman also said Meloni's trip was being "closely coordinated" with the institutions, and underlined that handling trade policy was a job for the EU.
The EU negotiates on behalf of all member states, and no single country can negotiate lower tariffs for its own benefit.
Meloni's team appears clear on this and Italian Foreign Minister Antonio Tajani said that Meloni "isn't going to negotiate for Italy against Europe but is going to champion a European stance".
Ultimately the Italian leader's mission may be to emphasise to Trump that the EU is keen to reach a zero-tariff agreement and commit to buying American – especially when it comes to defence and liquified natural gas (LNG).
And, in more hushed tones, she may also tell him that Europe is in no rush to make any deals with China.
"I don't know how public this will be but I think there will be some anti-China discourse as an incentive for the US administration," Riccardo Alcaro said.
At home, party allies were singing Meloni's praises before her plane to Washington even left the ground.
"This meeting shows Giorgia Meloni's courage and stature," said Brothers of Italy (FdI) MP Augusta Montarulli - although Senator Giovanbattista Fazzolari, somewhat less encouragingly, warned the trip would be "full of potential pitfalls".
And centre-left opposition parties took the opportunity to berate Meloni's proximity to the Trump administration.
"I have a feeling that upon her return Meloni will be flying the Trump flag rather than Italy's or Europe's," said Peppe Provenzano of the Democratic Party (PD).
"I hope to be proven wrong."
At an awards ceremony in Rome on Tuesday, Meloni addressed a room packed with entrepreneurs and business leaders – the very same who stand to lose the most from Trump's tariffs.
Looking ahead to her trip to Washington, she chuckled nervously.
"As you can imagine," she joked, "I'm feeling no pressure at all."