The first baby born as a result of a womb transplant was in Sweden in 2014. Since then around 135 such transplants have been carried out in more than a dozen countries, including the US, China, France, Germany, India and Turkey. Around 65 babies have been born.
Originally scheduled to take place in late 2019, the sisters' transplant operation fell through and then looked in doubt for several years during the Covid pandemic.
When it eventually took place, in February 2023, it took a team of more than 30 medics around 17 hours to remove Amy's womb and transplant it to Grace.
Isabel Quiroga, the surgeon who led the transplant team at the Churchill Hospital in Oxford, says although the procedure carried risks for both sisters, it was "life-enhancing and life-creating - and you can't have better than that."
Amy says she did not feel the sense of loss some women experience after a hysterectomy, because of the "dramatic" and immediate benefits to her sister. Grace had her first ever period within two weeks of the transplant and became pregnant on the first attempt at IVF.
It was "incredible" to feel her baby's first kick, she says, adding the entire pregnancy had been "really special".
