In 2009, they played in Oslo as Barack Obama was awarded the Nobel peace prize; and in 2011 staged a series of concerts in the dark, to show audiences how they experienced music.
A year later, they decided to record two versions of their sixth album Folila - one in New York and one with traditional musicians in Bamako.
The idea was to release each separately but, in the end, the duo decided to combine the recordings, mixing different takes of the same song together in a third studio in Paris.
Featuring contributions from Santigold, the Yeah Yeah Yeahs and TV On The Radio, it earned the group a second Grammy nomination in 2012.
2017's La Confusion, addressed the political turmoil in their homeland, where Islamic extremists had imposed Shariah law and banished music.
Songs like Bofou Safou offered messages of strength, resistance and optimism amidst the turmoil. Bagayoko said he hoped the music was universal
"We started to work on the things that were happening in our homeland, but then realised that they could be applied to a lot of other countries in the world," he told OkayAfrica.
"There is a confusion all over the world, and it's time to communicate, to talk and share ideas for a better future and understanding."
The duo continued to record and tour until last year. Bagayoko's final performance came at the closing ceremony of the Paris 2024 Paralympic Games.
As of Sunday, the duo's website still listed dates for a European tour in May and June.
He is survived by his wife and a son, Sam, also a musician.
Bagayoko "will be buried in family intimacy in the courtyard of his home", his spokesman Djiby Sacko told the AFP news agency.