The rising star, who has been mentioned as potential future James Bond, previously appeared opposite Sheffield actor Bean in another Merseyside crime drama, Time.
And he has featured alongside another Liverpudlian, Stephen Graham, in Time, Little Boy Blue, and the recent historical drama A Thousand Blows.
He says his latest character's respect for his partner in crime, Ronnie, was a mirror of his real life working relationship with Bean, who he describes as "a gift" of a co-star and a "kind human being".
Graham is "so supportive" of Nelson-Joyce's career too. The former's own headline-grabbing new show, Adolescence, also tackles toxic masculinity and its potentially deadly effects.
This City is Ours' Bafta-winning director Saul Dibb (The Sixth Commandment) notes how Nelson-Joyce has played "hard men" roles before but has not been able to demonstrate "all of the other qualities" he possesses, until now.