Cardiff Metropolitan University has said it expects to make between 30 and 50 staff redundant, as it tries to cut costs.
It is the latest Welsh institution to move to compulsory job losses to address financial pressures facing the sector.
Cardiff Met, which employs around 1800 staff according to the latest data, said it had already implemented a range of measures to minimise the need for compulsory redundancies, but further reductions were required.
In January, Cardiff University published proposals to cut 400 jobs, while Bangor University and the University of South Wales are also consulting on job losses.