Staff at the University of Sheffield have voted to go on strike over "drastic" restructuring plans which aim to save £23m over two years.
The University and College Union (UCU) said up to 1,000 jobs would be put at risk by the plans, which have seen the number of academic departments cut by more than half.
The university said it would not be making that many staff redundant, with a "significantly lower" number of jobs affected.
Three quarters of voters backed strike action after the university did not agree to make zero compulsory redundancies during the restructure.