Major cutbacks are planned at NHS England as part of government plans to "avoid duplication" with the Department of Health and Social Care.
It means around 6,500 jobs are at risk, about half the workforce at NHS England, with the aim of saving £175 million a year.
The news comes as it emerged three more NHS England board members will leave.
This follows recent announcements that chief executive Amanda Pritchard and medical director Sir Stephen Powis will quit.
NHS England was established in 2013 by former Tory health secretary Andrew Lansley to give it greater independence and autonomy.