Meetings are being held with staff and unions amid concern that hundreds of jobs are under threat at Cardiff University.
Academic departments have been summoned to briefings with managers with speculation that some departments could be merged and subjects affected.
Chair of the University and College Union (UCU) Cymru Estelle Hart said there had been a "lack of communication" by university bosses which was causing "anxiety" to staff.
A Cardiff University spokesperson said that staff and students would be the first to know if any changes were proposed.