Ofwat chief executive David Black said the investment would significantly cut sewage spills, reduce leaks and ensure customers get a better service.
Some £104bn can be spent on upgrading water systems, which will mean "cleaner rivers and seas and secure long-term drinking water supplies for customers", he said.
Bill hikes vary by region. Southern Water customers will be hit by the biggest increase, with bills going up 53% - to £642 on average - by 2030.
The news comes as supplies to more than 58,000 Southern Water customers are currently disrupted.
Wessex and Northumbrian Water bills will rise by the smallest amount, 21%.
Thames Water, which is struggling under a huge debt pile, will be able to charge customers 35% more, with annual bills going up to £588 in five years.
Bill rises are set by Ofwat for a five-year period, but firms can appeal against the decision by going to the Competition and Markets Authority.
Thames Water, which had asked to be allowed to put bills up by 53% to £667, said it was looking at the Ofwat decision.
Bills vary by region depending on how available water is, and whether people live in towns or the countryside, according to water industry dashboard Discover Water.
The bill rises do not apply to households in Scotland and Northern Ireland, where the water industry is nationalised.
In Wales, Dwr Cymru and Hafren Dyfrdwy will both increase bills by 42%, taking typical bills to £645 and £557 respectively.
Peter Perry, chief executive of Dwr Cymru, said there had been a "deficit over the last 15 years where bills haven't risen".
He said the firm would improve drinking water and 700km of rivers, and tackle sewage overflows, with £4bn of investment.