A vote of no-confidence in the government headed by Prime Minister Michel Barnier is taking place at the French National Assembly at around 19:00 (18:00 GMT).
If - as expected - the vote goes through, the Barnier government will collapse.
Barnier, the former EU Brexit chief negotiator, was picked by President Emmanuel Macron to be prime minister just 90 days ago.
Macron, who is currently on a state visit to Saudi Arabia, has said he still believes the Barnier government can survive the vote. "The country's interests are more important than those of the parties," he said.
But the left-wing alliance New Popular Front (NFP) and Marine Le Pen's far-right National Rally (RN) MPs already said they will cast their ballots against him, making it mathematically impossible for Barnier to remain in place.