Fed chair Jerome Powell said central bankers need time to see how the Fed's three cuts this year work their way through the US economy. Policymakers will closely examine incoming data leading up to Fed's next meeting in January, he added.
"We are well-positioned to wait to see how the economy evolves," Powell told reporters.
Those hoping for interest rates to keep coming down, including President Donald Trump, might have to wait.
The Fed is facing a "very challenging situation" as it confronts risks of rising inflation and unemployment, Powell said, adding: "you can't do two things at once".
The decision to lower rates on Wednesday was not unanimous, suggesting widening divisions among central bankers over the outlook for the US economy.
Three Fed officials broke ranks and officially dissented.
Stephen Miran, who is on leave from his post leading Trump's Council of Economic Advisers, voted for a larger 0.5 percentage point cut.
Austan Goolsbee, president of the Federal Reserve Bank of Chicago, and Jeffrey Schmid, president of the Federal Reserve Bank of Kansas City, voted to hold rates steady.
Trump, who has repeatedly urged Powell to lower rates, said after the meeting on Wednesday that the Fed's cut could have been "at least doubled".
"Our rates should be much lower," he said at a roundtable at the White House. "We should have the lowest rates in the world."