Born in Toronto in 1929, Gehry moved to Los Angeles as a teenager to study architecture at the University of Southern California, before completing further study at the Harvard Graduate School of Design in 1956 and 1957.
After starting his own firm, he broke from traditional architectural principles of symmetry, using unconventional geometric shapes and unfinished materials in a style now known as deconstructivism.
Through blending unexpected materials and sheathing buildings in stainless steel to create curvy exteriors, Gehry created buildings that took on arresting sculptural shapes.
Later in his career, Gehry used 3D modelling similar to that used by aerospace engineers to shape windy buildings, a practice largely avoided by other architects because of the complexity and costliness of construction.
In 1989, at the age of 60, Gehry was awarded the industry's top accolade, the Pritzker Architecture prize, for lifetime achievement.
The Pritzker jury said his work possessed a "highly refined, sophisticated and adventurous aesthetic".
"His designs, if compared to American music, could best be likened to Jazz, replete with improvisation and a lively unpredictable spirit," the panel said at the time.
Gehry's international breakthrough with the Guggenheim transformed the city of Bilbao, boosting tourism to the city and the local economy. Crafted out of titanium sheets, limestone, and glass, the museum was instantly celebrated as a modern marvel.
Architect Philip Johnson, Gehry's American contemporary, described the structure as "the greatest building of our time".
Other cities tried to replicate its success, branded the "Bilbao effect", where investment in daring art could revitalise ailing economies.
The cultural phenomenon was parodied in a 2005 episode of The Simpsons, in which the fictional town of Springfield invites Gehry, who voiced himself in the cartoon TV show, to design a new concert hall.
In the episode, the shape of the concert hall is jokingly inspired by a letter Gehry had scrunched up.
The guest appearance later "haunted" Gehry, who told the Observer in 2011 that people sincerely believed his real-life designs were inspired by crumpled paper instead of complex computations.