Presidents in Honduras can only serve a single four-year term so the incumbent, Xiomara Castro, who was the country's first female president when she took office in 2021 for the Libre party, is not on the ballot.
She has backed Moncada to take her place. The 60-year-old lawyer has pledged to protect "natural wealth" from "21st-century filibusters who want to privatise everything" if she wins. Moncada has also expressed her commitment to combating corruption "in all its forms".
On Saturday, Moncada accused Trump of meddling in the election, calling his endorsement of her right-wing opponent "totally interventionist".
Trump had said that the US would be "very supportive" if Tito Asfura wins Sunday's presidential election, which will also see voters choose all 128 members of congress and almost 300 local representatives.
"If he doesn't win, the United States will not be throwing good money after bad, because a wrong Leader can only bring catastrophic results to a country, no matter which country it is," Trump wrote on his social media platform, Truth Social.
The US sent more than $193m (£146m) to Honduras last fiscal year, according to the State Department website, and despite aid cuts, has sent more than $102m this year. The Trump Administration has already reportedly cut $167m in economic and governance aid that had been earmarked for 2024 and 2025, the Congress website says.
In another post, Trump wrote that he and Asfura, who is the former mayor of the capital, Tegucigalpa, could "work together to fight the Narcocommunists" and counter drug trafficking.
Nasry Asfura has pledged in a series of social media posts to bring "development and opportunities for everyone", to "facilitate foreign and domestic investment into the country" and "generate employment for all."
However, his party has been plagued by scandals and corruption accusations in recent years - including the sentencing of former party leader and ex-president Juan Orlando Hernández last year.
Hernández was jailed for 45 years in the US on drug-smuggling and weapons charges - a decision Trump now intends to overturn.
Asfura has carefully tried to distance himself from Hernández. On Friday he told news agency AFP that he has "no ties" with the ex-president, and that "the party is not responsible for his personal actions."