Prof Simon Middleburgh, director of the Nuclear Futures Institute at Bangor University, said the SMRs would be "built in a modular manner in factories and shipped to the site to be put together a bit like an Ikea chair".
There were "a few more hurdles to go through", he cautioned - from securing regulatory approval, building the factories required to construct the SMRs and training the workforce that will run them.
Opponents of the project point to the fact that a long-term storage facility for the UK's nuclear waste is yet to be agreed upon and say investment in renewable energy schemes - wind, wave and tidal - is what Anglesey needs.
Dylan Morgan, of the People Against Wylfa-B campaign group, said the proposed SMRs were "an unnecessarily big development of an unproven technology".
The government sees them as a secure, reliable, affordable and low carbon energy system and is convinced that, with investment, SMRs will create thousands of jobs and boost manufacturing.
Wylfa beat competition from a site at Oldbury in Gloucestershire, with the reactors designed by Rolls-Royce, subject to final contracts, which are expected later this year.
The UK government said the plant would help provide energy independence.
The decision to opt for small modular reactors at Wylfa was criticised by the US ambassador Warren Stephens, who said he was "extremely disappointed".
He had urged ministers to commit to a large-scale plant, with US firm Westinghouse having reportedly presented plans for a new gigawatt station at the site.
Downing Street said the decision to build the power station in Wales "doesn't close the door" to a US manufacturer working on a future project.