Ulster back row Cormac Izuchukwu and Leinster hooker Gus McCarthy will make their Ireland debuts in Saturday's Test against Fiji, with Sam Prendergast handed a first start at fly-half.
Izuchukwu, 24, is named at blind-side flanker with Tadhg Beirne moving into the second row, while 21-year-old Leinster front row McCarthy replaces Ronan Kelleher.
Prendergast, 21, will make his full debut after replacing Jack Crowley for the final 20 minutes of last week's narrow win over Argentina.
Also in the backs, Jamie Osborne replaces Hugo Keenan at full-back, Bundee Aki returns in midfield, Craig Casey is named at scrum-half and Ulster's Jacob Stockdale is recalled to the left wing as Farrell makes seven changes to face Fiji, who beat Wales in Cardiff earlier this month.
"There were signs of improvement last weekend and this week has been about building and embracing the challenge of a talented Flying Fijian side who will be coming over to Dublin full of confidence after their recent displays," said Farrell.