Last month, talks broke down between Streeting and pharma firms over the cost of medicines for the UK.
The UK government said at the time it had put forward a "generous and unprecedented offer to accelerate growth" in the pharmaceutical sector.
Streeting previously insisted that he would not allow pharma companies to "rip off" taxpayers and described drug companies' approach as "short-sighted".
However, he struck a more conciliatory tone on Wednesday saying "it's a live conversation – not just domestically with the industry but internationally with the US as well".
"There's an intersection between the growth ambitions of the government, the health ambitions of the government, the trade ambitions of the government and bilateral relations with the US," he added.