The case has not just shocked France, it has attracted interest from around the world. It has highlighted the issue of drug-induced sexual assault and raised questions about whether consent should become part of the French definition of rape.
Warning: Some of the details in this report are graphic from the start
Tuesday's session was the last chance that lawyers for the men on trial for rape might have to convince the judges that her ex-husband Dominique Pelicot had somehow tricked them into raping her while she was unconscious.
About 15 defendants sat in the defendants' box while Dominique Pelicot sat in another box, resting his chin on his hand. A handful of the 50 admit raping Gisèle Pelicot, but the majority do not.
Dominique Pelicot was asked whether he accepted that he had manipulated the other defendants into raping his wife or if he had drugged them, he said firmly: "Absolutely not."
He suggested they had used that defence "to save themselves".
Gisèle Pelicot's lawyer also asked him what he had to say to his family, especially his daughter Caroline.
Partially naked images of Caroline were found on Dominique Pelicot's laptop, and when asked about the file he had called "my naked daughter", he addressed her across the room: "I have watched her fall apart... Caroline, I never touched you."
She shouted across the court: "You are lying; I am sick of your lies, you're alone in your lie, you will die lying."
There was complete silence as they looked at each other and Dominique Pelicot then held his head in his hands.
The rest of the family, their faces filled with anguish, stared at him, while Gisèle Pelicot herself did not react.