Although it stung not to be successful in her home country, these days she "can't even imagine putting America into my life."
"I'm already working enough," she laughs. "I'm exhausted."
She can trace the change of heart back to 2003, when she performed at 46664, an Aids benefit concert organised in South Africa by Nelson Mandela.
"I was backstage and Beyoncé and Bono were talking to me, saying, 'God, I would love to have a country where I could walk around and people would think I was just a regular person'," she recalls.
"I was like, 'I never thought about it that way'. And in hindsight, I'm very grateful."
That glass-half-full optimism has been a hallmark of Anastacia's career. It kept her going through the years where she was considered un-signable; and was the foundation of her comeback after surviving breast cancer, twice.
As fate would have it, the 25th anniversary of Not That Kind has coincided with a resurgence of Anastacia's music on social media.
"I used to think I'm Outta Love would always be my biggest song and, lo and behold, Left Outside Alone has surpassed that.
"And interestingly enough, Paid My Dues gets a very strong reaction at the minute - I think they just like all the sass that comes from that song."
Inspired by that success, the singer has not one but two new albums cooking on the stove. She'll head back to the studio after wrapping up her tour this autumn, but can't confirm when the music will see the light of day.
"After all these years, the music industry is still a mystery," she says.
"It's still a mystery, and it's always like, 'Don't worry, you have plenty of time… Hurry up. We need it tomorrow'."