Harry will arrive in London on Monday to attend an awards ceremony for WellChild, which supports seriously ill children and their families. The prince has been a patron for 17 years.
"I am always privileged to attend the WellChild Awards and meet the incredible children, families and professionals who inspire us all with their strength and spirit," he said announcing his return to the UK.
Tuesday's event will be held at the Community Recording Studio (CRS) in Nottingham, a charity that teaches film and video skills as well as music.
He will also hold a private briefing with Children in Need, the Police and Crime Commission, CRS and Epic Partners, and will have informal meetings with some of the young people he has met previously.
The duke will also watch live performances from artists, and make a short speech.
Buckingham Palace has not commented on the possibility of a meeting between the King and the duke during this trip. Nor has Harry and Meghan's team.
But recently, there have been signs that tensions between father and son are easing, and that a reconciliation could be within reach.
His father was in Italy on a state visit during the prince's April trip to London.
This time, the King will be in the UK. He has spent most of the summer in Scotland at his Balmoral Estate but is regularly travelling south for cancer treatment and some royal engagements. It leaves open the real possibility of father and son meeting in person.