Dame Angela and Dame Diana have been moved to roles in other departments, with Sarah Jones and Alex Norris brought into the Home Office, to work with new Home Secretary Shabana Mahmood.
The Dover MP Mike Tapp, who frequently contributes to the debate about small boats and is a vociferous critic of Reform leader Nigel Farage, has also become a home office minister.
The moves reflects the importance the PM places on tackling illegal immigration and stopping small boat crossings.
Anna Turley has been promoted from the Whips Office to minister without portfolio in the Cabinet Office, and will attend cabinet. She will also become Labour Party chair, replacing Chancellor Rachel Reeves's sister Ellie.
Ellie Reeves becomes Solicitor General, replacing Lucy Rigby, who is moving to the Treasury to become economic secretary, effectively third in command to Rachel Reeves.
Sir Keir has sacked farming minister Daniel Zeichner, having also moved environment secretary Steve Reed to Rayner's old housing brief - perhaps a sign that he wants to reset the government's shattered relationship with the farming community.
Another appointment that stands out is Jason Stockwood, vice-chairman of Grimsby Town football club.
Stockwood is a local-boy-done-very-well in business, so much so that some in the party were keen to see run as a candidate in a parliamentary seat.
He was not interested, but has been lured into the Lords and becomes a business minister.
For a government frequently criticised for lacking voices with long-standing private sector experience, the soon-to-be Lord Stockwood could prove something of an asset.
Former investment minister Poppy Gustaffson and former local government minister Jim McMahon have also left government, Downing Street confirmed.
