"I'm looking forward to being on the close again after all these years."
The Grant family launched Brookside, which began on the first night of Channel 4 in 1982.
Audiences quickly warmed to the married couple as they settled into their first-owned home with their three children.
The pair were joined on set by Brookside favourites including Paul Usher as Barry Grant, John McArdle as Billy Corkhill, Philip Olivier as Timothy "Tinhead" O'Leary, Suzanne Collins as Nikki Shadwick and Michael Starke as Thomas "Sinbad" Sweeney.
Conceived by Sir Philip Redmond, who had already created school drama Grange Hill and went on to create Hollyoaks, Brookside drew in audiences of nine million viewers at its peak before it broadcast for a final time on 4 November 2003.
The show, set in Liverpool, was known for its hard-hitting storylines and took on issues surrounding issues including rape, bullying and incest.
This will be the first time that Brookside Close has been on air since it ended.
The series famously concluded with Jimmy Corkhill, played by the late Dean Sullivan, daubing a letter "d" on to the sign, leaving it as "Brookside Closed" before driving out of the cul-de-sac.
The one-off episode is set to air next month.