Capturing such a scene in a "non-intrusive way" requires a huge collaborative effort from a top team of scientists and cinematographers, he adds.
"The spiderlings are about the size of a grain of sugar, and the adults are about the size of your thumbnail. So it's a very small world that you're in."
Wilson warns viewers will be left "shivering with disgust" while also "amazed with the wonder of it all".
Aside from the heroically maternal spiders, other potential breakout viral stars of this series include:
As hi-tech close-up images draw us into their worlds, their stories are also driven along in dramatic, heart-rending fashion by a bittersweet musical score courtesy of British composer Tom Howe (who also worked on Mulan and Ted Lasso).
The series also includes a theme song by Sam Ryder, recorded at Abbey Road, which Wilson hopes will become a hit.
All of which brings us back to the show's famous narrator, Sir David, who - at 99 years old - is still providing "special" and "unique" TV moments, his director tell us.
And always in no more than two takes.
"There can be very few people on Earth who have the ability to communicate to an audience from two [years old] to 102, and feel like they're communicating it at their level," says Wilson, who is also series producer.
"And that's not [just] Sir David as we see him on screen, that's Sir David in real life."
He continues: "When you're working with a partner who understands the natural world as well, if not better than you do, that's always exciting."