Black Sabbath reunited at regular intervals, and in 2013 went back to the top of the UK album chart - 43 years after their last number one, Paranoid.
In 2018, he claimed to have ditched the alcohol and the drugs and would be reining in his touring lifestyle.
"I have grandchildren now and I'm 70 years old and I don't want to be found dead in a hotel room somewhere," he told a journalist while promoting Ozzfest that year.
However, he had other health issues to contend with.
At first, he thought the shaking in his hands was a result of his lifetime of excess. But in 2007 he was diagnosed with a condition called Parkinsonian syndrome, then in 2019 with Parkinson's disease.
He suffered spinal damage in a late-night fall the same year, which aggravated the injury he sustained in the quad-bike crash. Repeated surgeries had limited success.
But he was determined to bow out of the public eye with a customary bang.
He, Sharon and his old Black Sabbath bandmates lined up a farewell concert at Villa Park football stadium, a stone's throw from his childhood home, which took place just over two weeks ago.
An array of fellow rock legends - including Metallica, Guns N' Roses and Aerosmith's Steven Tyler - lined up to perform and pay homage to him and Sabbath's influence.
Osbourne himself performed seated because of his mobility problems, but managed to recapture his old magic - belting out his hits while clapping, waving his arms and pulling wild-eyed looks, just like old times.
"I'm proud of what I've achieved with my life," he once told an interviewer. "You couldn't have written my life story if you'd been the best writer in the world".