ACL injuries can happen at all stages of the menstrual cycle, but hormonal changes are also being investigated, including a study sponsored by Fifa, the governing body for world football.
High levels of oestrogen prior to ovulation could alter the properties of ligaments, making them a bit more stretchy so "there could be an increased risk of injury, theoretically," he says.
But Dr Dos'Santos argues it's important to think beyond pure anatomy as women still do not get the same quality of support and strength training as men.
He compares it to ballet, where dancers do receive good quality training. "The [difference in] incidence rates is basically trivial between men and women," Dr Dos'Santos says.
There is research into whether it is possible to minimise the risk of ACL injuries, by training female athletes to move in subtly different ways.
But there is a risk of lessening performance, and some techniques that put strain on the ACL – like dropping the shoulder to deceive a defender before bursting off in another direction – are the necessary moves in sports like football.
"We can't wrap them up in cotton wool and say you should avoid playing sport," Dr Dos'Santos says. "What we need to do is make sure that they're strong enough to tolerate those loads, but it isn't just as simple as some people saying we can 100% eradicate ACL injuries, we can't."