Earlier in the day, the official setlist had advertised two Drake sets - one at 18:25 and one at 20:55.
The first mysteriously disappeared from the schedule during the course of the afternoon, with planned performances from Vybz Kartel and Burna Boy going ahead in their allotted time slots.
Fans appeared surprised when Drake entered the stage just minutes after Burna Boy had finished, with the Canadian announcing himself to the crowd by speaking to fans.
He appeared agitated, which was a departure from his more upbeat attitude from Friday and Saturday night.
Drake started his set by playing an unreleased collaboration with British rapper Central Cee, who did not appear on stage to perform but instead mouthed the words from his position in the front row, which was projected across the big screens.
The Toronto rapper and singer appeared apologetic throughout, promising to play some of his biggest hits to win over the crowd.
He told the crowd: "London, I will love you for the rest of my life," as he raced through a medley of tracks.
They included Controlla, Find Your Love and One Dance, which were remixed and updated for 2025, but felt slightly rushed, with their new arrangements making it difficult for fans to sing along.
A surprise appearance from Nigerian rapper Rema raised spirits in the crowd, with tracks Calm Down and Fever proving a highlight.
But after a brief cameo from Jamaican dancehall artist Vybz Kartel, who had performed to a huge crowd earlier in the day, there was only time for two more Drake solo songs.
For the third night in a row, he climbed onto a crane to wave to the 50,000 attendees as Whitney Houston's I Will Always Love You blasted through the speakers.
