Cian Healy is set to equal Brian O'Driscoll's Ireland cap record after being named on the bench for Friday's autumn international against Argentina, while Sam Prendergast and Thomas Clarkson are set to make their debuts.
The 37-year-old prop will draw level with the former Ireland captain on 133 appearances if he is introduced against the Pumas.
Head coach Andy Farrell has opted against making wholesale changes following last week's defeat by New Zealand, with Robbie Henshaw's inclusion at inside centre ahead of Bundee Aki - who does not make the squad - the only alteration to the starting line-up.
Prop Clarkson and fly-half Prendergast are primed to earn their first caps after being named among the replacements.
Argentina named their team earlier on Wednesday with head coach Felipe Contepomi making three changes from last weekend's resounding win over Italy.