The atmosphere in court on Tuesday was tense - as the rapper sat with head bowed, hands folded in his lap. His lawyers occasionally put their arms around him.
Over the past two months, the jury has heard from 34 witnesses, including ex-girlfriends, former employees of Mr Combs, male escorts and federal agents.
Mr Combs is charged with racketeering conspiracy, two charges of sex trafficking and two charges of transportation to engage in prostitution.
At around 16:30 EDT on Tuesday (20:30 GMT), the jury announced they had reached a verdict on four of the five counts, after two days of deliberations.
The panel said they could not come to an agreement on the racketeering charge because jurors on both sides had opinions that were unmovable.
Judge Arun Subramanian heard arguments from both the prosecution and the rapper's defence attorneys on how to proceed, before urging the jurors to keep trying to come to a unanimous decision. Their verdicts on the other four counts were not disclosed.
The prosecution urged the judge to use an Allen charge, which is a set of instructions given to a hung jury to press its members to reach a unanimous decision.
Allen charges are controversial, as some believe they can put undue pressure on juries, forcing them to change their stances or cave to peer pressure - especially when their opinion is in the minority.
As well as returning to court on Wednesday, the jurors could potentially continue deliberating on 3 July - when the court is normally closed ahead of the 4 July public holiday.