More than half of the top 15 hotspot areas for uninsured drivers are within the West Midlands region, latest figures show.
The two worst offending postcodes were B11 and B21 in Birmingham, and WV2 in Wolverhampton was in fourth place, according to claims data from the Motor Insurers' Bureau (MIB).
West Midlands Police seized more than 6,500 uninsured vehicles last year, Paul Farley from the MIB said.
"It is a challenge, the police are doing lots of work and we're really trying to make a difference," he said.