Fake artworks attributed to more than 30 famed artists were seized in raids carried out in Italy, Spain and Belgium, the statement said.
Other artists impersonated by the network included Claude Monet, Vincent Van Gogh, Salvador Dali, Henry Moore, Gustav Klimt, Joan Mirò, Jackson Pollock, Francis Bacon and Piet Mondrian.
Pisa Chief Prosecutor Teresa Angela Camelio said experts believe the operation is "the biggest act of protection" of Banksy's estate.
Banksy is one of the world's most famous artists, but despite his global following, his identity remains, officially at least, unknown.
This is not the first time his artwork has attracted criminals. In September, two thieves were arrested and charged over the theft of his famed Girl with Balloon piece from a central London art gallery.
Banksy’s art, which tends to be graffitied by the artist on public buildings, has at times not remained intact for long.
A recent urban jungle collection, which popped up over a series of days across London, was defaced.
Warhol’s work, too, has fallen foul of criminals of late. Earlier this month two of his artworks were stolen during an overnight break-in at a gallery in the Netherlands.